Immune responses to Schistosoma haematobium infection

Document Type

Journal Article

Publication Date

1-1-2014

Journal

Parasite Immunology

Volume

36

Issue

9

DOI

10.1111/pim.12084

Keywords

Immune modulation; Immunoepidemiology; Schistosoma haematobium; Schistosoma spp; Schistosomiasis; Urogenital

Abstract

© 2013 John Wiley & Sons Ltd. Urogenital schistosomiasis is one of the greatest single infectious sources of human morbidity and mortality known. Through a complex cycle of infection, migration and eventual maturation and mating, S. haematobium (the aetiological agent of urogenital schistosomiasis) deposits highly immunogenic eggs within the bladder and other pelvic organs, activating a wide range of immune programs that determine both infection outcome as well as downstream immunopathology. In this review, we discuss the experimental and observational bases for our current understanding of these immune programs, focusing specifically on how the balance of type 1 and type 2 responses governs subsequent immunopathology and clinical outcome.

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