Extremity Findings of Methotrexate Embryopathy
Document Type
Journal Article
Publication Date
1-1-2020
Journal
Hand
Volume
15
Issue
1
DOI
10.1177/1558944719837657
Keywords
embryopathy; extremity; methotrexate; oligodactyly
Abstract
© The Author(s) 2019. Background: Methotrexate (MTX) is widely used as an immunosuppressant, chemotherapeutic, and abortifacient agent. It is also a potent teratogen, and intentional or unintentional exposure during pregnancy is associated with heterogeneous birth anomalies. Methods: We retrospectively reviewed a cohort of patients who presented to our clinic with limb anomalies in the setting of MTX embryopathy. Results: In our case series, we describe 7 cases of patients who had limb anomalies with heterogeneous functionality, from severely debilitating to completely asymptomatic. Most of the upper extremity anomalies in our group were managed conservatively. Conclusions: Methotrexate embryopathy is a rare but clinically important entity with phenotypic and functional variability. This series underscores the need for proper counseling of patients and raises concern regarding using this medication for the purpose of abortion.
APA Citation
Mantilla-Rivas, E., Brennan, A., Goldrich, A., Bryant, J., Oh, A., & Rogers, G. (2020). Extremity Findings of Methotrexate Embryopathy. Hand, 15 (1). http://dx.doi.org/10.1177/1558944719837657