Laparoscopic Splenectomy for Autoimmune Hemolytic Anemia in Patients with Chronic Lymphocytic Leukemia: A Case Series and Review of the Literature

Authors

John Hill, Cleveland Clinic Foundation
R. Matthew Walsh, Cleveland Clinic Foundation
Scott McHam, Cleveland Clinic Foundation
Fred Brody, Cleveland Clinic Foundation
Matt Kalaycio, Cleveland Clinic Foundation

Document Type

Journal Article

Publication Date

3-1-2004

Journal

American Journal of Hematology

Volume

75

Issue

3

DOI

10.1002/ajh.10472

Keywords

Anemia; Autoimmune; Hemolysis; Leukemia; Splenectomy

Abstract

The purpose of this study was to evaluate the safety and efficacy of laparoscopic splenectomy in patients with chronic lymphocytic leukemia (CLL) complicated by autoimmune hemolytic anemia. A series of nine such patients who underwent this procedure at our institution between August 1997 and September 2001 were retrospectively reviewed. Seven of 9 patients who underwent laparoscopic splenectomy for CLL and autoimmune hemolytic anemia achieved a complete response. One patient who initially responded relapsed 12 weeks postoperatively. Therefore, six of 9 patients showed sustained responses with a mean follow-up of 2 years, consistent with other published series. Two patients had no response, one of whom died within 3 weeks of surgery from transformed Hodgkin's disease. The only other postoperative complication occurred in a patient who developed pneumonia. We conclude that laparoscopic splenectomy is a safe and effective treatment for autoimmune hemolytic anemia in patients with CLL who fail medical therapy. © 2004 Wiley-Liss, Inc.

APA Citation

Hill, J., Walsh, R., McHam, S., Brody, F., & Kalaycio, M. (2004). Laparoscopic Splenectomy for Autoimmune Hemolytic Anemia in Patients with Chronic Lymphocytic Leukemia: A Case Series and Review of the Literature. American Journal of Hematology, 75 (3). http://dx.doi.org/10.1002/ajh.10472