Title

Clinical benchmark for healing of chronic venous ulcers

Authors

Ross T. Lyon, Albert Einstein College of Medicine of Yeshiva University
Frank J. Veith, Albert Einstein College of Medicine of Yeshiva University
Laura Bolton, Albert Einstein College of Medicine of Yeshiva University
Fidelis Machado, Albert Einstein College of Medicine of Yeshiva University
Donald Belsito, Albert Einstein College of Medicine of Yeshiva University
John Blebea, Albert Einstein College of Medicine of Yeshiva University
Lloyd Cleaver, Albert Einstein College of Medicine of Yeshiva University
Anthony Comerota, Albert Einstein College of Medicine of Yeshiva University
G. Richard Curl, Albert Einstein College of Medicine of Yeshiva University
Herbert Dardik, Albert Einstein College of Medicine of Yeshiva University
James Dennis, Albert Einstein College of Medicine of Yeshiva University
Bo Eklof, Albert Einstein College of Medicine of Yeshiva University
Vincent Falanga, Albert Einstein College of Medicine of Yeshiva University
Louis Falo, Albert Einstein College of Medicine of Yeshiva University
Duyen Faira, Albert Einstein College of Medicine of Yeshiva University
Jay Fisher, Albert Einstein College of Medicine of Yeshiva University
Thomas Garland, Albert Einstein College of Medicine of Yeshiva University
David Gilepsie, Albert Einstein College of Medicine of Yeshiva University
Mitchel Goldman, Albert Einstein College of Medicine of Yeshiva University
Adelaide Herbert, Albert Einstein College of Medicine of Yeshiva University
Jamal Hoballah, Albert Einstein College of Medicine of Yeshiva University
John Hugill, Albert Einstein College of Medicine of Yeshiva University
William Krupski, Albert Einstein College of Medicine of Yeshiva University
Benjamin Levy, Albert Einstein College of Medicine of Yeshiva University
Joann Lohr, Albert Einstein College of Medicine of Yeshiva University
Mark Meissner, Albert Einstein College of Medicine of Yeshiva University
James O. Monzoian, Albert Einstein College of Medicine of Yeshiva University
William Mullcian, Albert Einstein College of Medicine of Yeshiva University
Jeffrey Olin, Albert Einstein College of Medicine of Yeshiva University
Tania Phillips, Albert Einstein College of Medicine of Yeshiva University
John Porter, Albert Einstein College of Medicine of Yeshiva University
John J. Ricotta, Albert Einstein College of Medicine of Yeshiva University
Robert Scheinfeld, Albert Einstein College of Medicine of Yeshiva University

Document Type

Conference Proceeding

Publication Date

8-1-1998

Journal

American Journal of Surgery

Volume

176

Issue

2

DOI

10.1016/S0002-9610(98)00136-6

Abstract

BACKGROUND: To determine the results of standardized ulcer treatment regimes and effects of the oral thromboxane A2 antagonist Ifetroban (250 mg daily) on healing of chronic lower-extremity venous stasis ulcers. METHODS: In a prospective, randomized, double blind, placebo-controlled multicenter study, 165 patients were randomized to Ifetroban (n = 83) versus placebo (n = 82) for a period of 12 weeks. Both groups were treated with sustained graduated compression and hydrocolloid. Ulcer size was measured weekly by tracings and computerized planimetry. A total of 150 patients completed the study. RESULTS: Complete ulcer healing was achieved after 12 weeks in 55% of patients receiving Ifetroban and in 54% of those taking a placebo with no significant differences; 84% of ulcers in both groups achieved greater than 50% area reduction in size. CONCLUSIONS: These results are likely to be useful as a benchmark for comparison with other treatment protocols concerning the care of chronic lower-extremity stasis ulcers.

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