Title

Bench-to-clinic development of imageable drug-eluting embolization beads: Finding the balance

Document Type

Journal Article

Publication Date

11-1-2018

Journal

Future Oncology

Volume

14

Issue

26

DOI

10.2217/fon-2018-0196

Keywords

cone-beam computed tomography; drug-eluting bead; radiopacity; radiopaque bead; transarterial chemoembolization

Abstract

© 2018 Future Medicine Ltd. This review describes the historical development of an imageable spherical embolic agent and focuses on work performed in collaboration between Biocompatibles UK Ltd (a BTG International group company) and the NIH to demonstrate radiopaque bead utility and bring a commercial offering to market that meets a clinical need. Various chemistries have been investigated and multiple prototypes evaluated in search of an optimized product with the right balance of handling and imaging properties. Herein, we describe the steps taken in the development of DC Bead LUMI™, the first commercially available radiopaque drug-eluting bead, ultimately leading to the first human experience of this novel embolic agent in the treatment of liver tumors.

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