Bench-to-clinic development of imageable drug-eluting embolization beads: Finding the balance
Document Type
Journal Article
Publication Date
11-1-2018
Journal
Future Oncology
Volume
14
Issue
26
DOI
10.2217/fon-2018-0196
Keywords
cone-beam computed tomography; drug-eluting bead; radiopacity; radiopaque bead; transarterial chemoembolization
Abstract
© 2018 Future Medicine Ltd. This review describes the historical development of an imageable spherical embolic agent and focuses on work performed in collaboration between Biocompatibles UK Ltd (a BTG International group company) and the NIH to demonstrate radiopaque bead utility and bring a commercial offering to market that meets a clinical need. Various chemistries have been investigated and multiple prototypes evaluated in search of an optimized product with the right balance of handling and imaging properties. Herein, we describe the steps taken in the development of DC Bead LUMI™, the first commercially available radiopaque drug-eluting bead, ultimately leading to the first human experience of this novel embolic agent in the treatment of liver tumors.
APA Citation
Lewis, A., Willis, S., Dreher, M., Tang, Y., Ashrafi, K., Wood, B., Levy, E., Sharma, K., Negussie, A., & Mikhail, A. (2018). Bench-to-clinic development of imageable drug-eluting embolization beads: Finding the balance. Future Oncology, 14 (26). http://dx.doi.org/10.2217/fon-2018-0196