Genetics and the central nervous system: apolipoprotein E and brain injury.
Document Type
Journal Article
Publication Date
1-1-1998
Journal
AACN clinical issues
Volume
9
Issue
4
DOI
10.1097/00044067-199811000-00007
Abstract
Apolipoprotein E (apoE), a protein produced by glial cells, is responsible for maintenance of the structural integrity of the microtubules within the axon of the neuron. The gene associated with apolipoprotein E, APOE, influences the construction and regeneration of the microtubules in an APOE allele-specific manner: APOE 2/2 may be neuroprotective, whereas APOE 4/4 may be neurodestructive. Thus, APOE appears to be one genetic factor that modifies the brain's response to insult, and therefore may modify the severity of neuropsychologic deficits. This article presents an overview of the genetic relation between APOE and neuropsychological function in Alzheimer disease and proposes a relation between APOE and recovery after head injury.
APA Citation
Kerr, M., & Kraus, M. (1998). Genetics and the central nervous system: apolipoprotein E and brain injury.. AACN clinical issues, 9 (4). http://dx.doi.org/10.1097/00044067-199811000-00007