Title

G protein-coupled receptors in major psychiatric disorders

Document Type

Journal Article

Publication Date

4-1-2007

Journal

Biochimica et Biophysica Acta - Biomembranes

Volume

1768

Issue

4

DOI

10.1016/j.bbamem.2006.09.025

Keywords

Bipolar disorder; Depression; Dopamine; G protein-coupled receptors (GPCRs); Glutamate; Schizophrenia; Serotonin

Abstract

Although the molecular mechanisms underlying psychiatric illnesses such as depression, bipolar disorder and schizophrenia remain incompletely understood, there is increasing clinical, pharmacologic, and genetic evidence that G protein-coupled receptors (GPCRs) play critical roles in these disorders and their treatments. This perspectives paper reviews and synthesizes the available data. Dysfunction of multiple neurotransmitter and neuropeptide GPCRs in frontal cortex and limbic-related regions, such as the hippocampus, hypothalamus and brainstem, likely underlies the complex clinical picture that includes cognitive, perceptual, affective and motoric symptoms. The future development of novel agents targeting GPCR signaling cascades remains an exciting prospect for patients refractory to existing therapeutics. © 2006 Elsevier B.V. All rights reserved.

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