G protein-coupled receptors in major psychiatric disorders
Document Type
Journal Article
Publication Date
4-1-2007
Journal
Biochimica et Biophysica Acta - Biomembranes
Volume
1768
Issue
4
DOI
10.1016/j.bbamem.2006.09.025
Keywords
Bipolar disorder; Depression; Dopamine; G protein-coupled receptors (GPCRs); Glutamate; Schizophrenia; Serotonin
Abstract
Although the molecular mechanisms underlying psychiatric illnesses such as depression, bipolar disorder and schizophrenia remain incompletely understood, there is increasing clinical, pharmacologic, and genetic evidence that G protein-coupled receptors (GPCRs) play critical roles in these disorders and their treatments. This perspectives paper reviews and synthesizes the available data. Dysfunction of multiple neurotransmitter and neuropeptide GPCRs in frontal cortex and limbic-related regions, such as the hippocampus, hypothalamus and brainstem, likely underlies the complex clinical picture that includes cognitive, perceptual, affective and motoric symptoms. The future development of novel agents targeting GPCR signaling cascades remains an exciting prospect for patients refractory to existing therapeutics. © 2006 Elsevier B.V. All rights reserved.
APA Citation
Catapano, L., & Manji, H. (2007). G protein-coupled receptors in major psychiatric disorders. Biochimica et Biophysica Acta - Biomembranes, 1768 (4). http://dx.doi.org/10.1016/j.bbamem.2006.09.025