Isolation and identification of Δ6-lithocholenic acid (3α-hydroxy-5β-6-cholen-24-oic acid) as an intestinal bacterial metabolite of chenodeoxycholic acid in man

Document Type

Journal Article

Publication Date

12-1-1985

Journal

Journal of Biological Chemistry

Volume

260

Issue

20

Abstract

Fecal bacterial biotransformation studies of chenodeoxycholic acid were performed. Incubations were carried out for 30-s to 12-h time intervals. Δ6-Lithocholenic acid was isolated by thin-layer chromatography. Its structure was confirmed by gas-liquid chromatography and mass spectrometry. The proportion of chenodeoxycholic acid biotransformed to Δ6-lithocholenic acid consistently ranged from 5.5 to 14.0%.

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