Isolation and identification of Δ6-lithocholenic acid (3α-hydroxy-5β-6-cholen-24-oic acid) as an intestinal bacterial metabolite of chenodeoxycholic acid in man
Document Type
Journal Article
Publication Date
12-1-1985
Journal
Journal of Biological Chemistry
Volume
260
Issue
20
Abstract
Fecal bacterial biotransformation studies of chenodeoxycholic acid were performed. Incubations were carried out for 30-s to 12-h time intervals. Δ6-Lithocholenic acid was isolated by thin-layer chromatography. Its structure was confirmed by gas-liquid chromatography and mass spectrometry. The proportion of chenodeoxycholic acid biotransformed to Δ6-lithocholenic acid consistently ranged from 5.5 to 14.0%.
APA Citation
Malavolti, M., Fromm, H., Cohen, B., & Ceryak, S. (1985). Isolation and identification of Δ6-lithocholenic acid (3α-hydroxy-5β-6-cholen-24-oic acid) as an intestinal bacterial metabolite of chenodeoxycholic acid in man. Journal of Biological Chemistry, 260 (20). Retrieved from https://hsrc.himmelfarb.gwu.edu/smhs_pharm_facpubs/935