Function and modulation of premotor brainstem parasympathetic cardiac neurons that control heart rate by hypoxia-, sleep-, and sleep-related diseases including obstructive sleep apnea
Document Type
Journal Article
Publication Date
1-1-2014
Journal
Progress in Brain Research
Volume
212
Issue
C
DOI
10.1016/B978-0-444-63488-7.00003-3
Keywords
Ambiguus; Apnea; Cardiac; Non-REM; Obstructive; Parasympathetic; REM; Serotonin; Sleep; Vagal
Abstract
© 2014 Elsevier B.V. Parasympathetic cardiac vagal neurons (CVNs) in the brainstem dominate the control of heart rate. Previous work has determined that these neurons are inherently silent, and their activity is largely determined by synaptic inputs to CVNs that include four major types of synapses that release glutamate, GABA, glycine, or serotonin. Whereas prior reviews have focused on glutamatergic, GABAergic and glycinergic pathways, and the receptors in CVNs activated by these neurotransmitters, this review focuses on the alterations in CVN activity with hypoxia-, sleep-, and sleep-related cardiovascular diseases including obstructive sleep apnea.
APA Citation
Dergacheva, O., Weigand, L., Dyavanapalli, J., Mares, J., Wang, X., & Mendelowitz, D. (2014). Function and modulation of premotor brainstem parasympathetic cardiac neurons that control heart rate by hypoxia-, sleep-, and sleep-related diseases including obstructive sleep apnea. Progress in Brain Research, 212 (C). http://dx.doi.org/10.1016/B978-0-444-63488-7.00003-3