Activation of Oxytocin Neurons Improves Cardiac Function in a Pressure-Overload Model of Heart Failure

Document Type

Journal Article

Publication Date

5-1-2020

Journal

JACC: Basic to Translational Science

Volume

5

Issue

5

DOI

10.1016/j.jacbts.2020.03.007

Keywords

heart failure; oxytocin; parasympathetic

Abstract

© 2020 The Authors This work shows long-term restoration of the hypothalamic oxytocin (OXT) network preserves OXT release, reduces mortality, cardiac inflammation, fibrosis, and improves autonomic tone and cardiac function in a model of heart failure. Intranasal administration of OXT in patients mimics the short-term changes seen in animals by increasing parasympathetic—and decreasing sympathetic—cardiac activity. This work provides the essential translational foundation to determine if approaches that mimic paraventricular nucleus (PVN) OXT neuron activation, such as safe, noninvasive, and well-tolerated intranasal administration of OXT, can be beneficial in patients with heart failure.

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