Activation of Oxytocin Neurons Improves Cardiac Function in a Pressure-Overload Model of Heart Failure
Document Type
Journal Article
Publication Date
5-1-2020
Journal
JACC: Basic to Translational Science
Volume
5
Issue
5
DOI
10.1016/j.jacbts.2020.03.007
Keywords
heart failure; oxytocin; parasympathetic
Abstract
© 2020 The Authors This work shows long-term restoration of the hypothalamic oxytocin (OXT) network preserves OXT release, reduces mortality, cardiac inflammation, fibrosis, and improves autonomic tone and cardiac function in a model of heart failure. Intranasal administration of OXT in patients mimics the short-term changes seen in animals by increasing parasympathetic—and decreasing sympathetic—cardiac activity. This work provides the essential translational foundation to determine if approaches that mimic paraventricular nucleus (PVN) OXT neuron activation, such as safe, noninvasive, and well-tolerated intranasal administration of OXT, can be beneficial in patients with heart failure.
APA Citation
Dyavanapalli, J., Rodriguez, J., Rocha dos Santos, C., Escobar, J., Dwyer, M., Schloen, J., Lee, K., Wolaver, W., Wang, X., Dergacheva, O., Michelini, L., Schunke, K., Spurney, C., Kay, M., & Mendelowitz, D. (2020). Activation of Oxytocin Neurons Improves Cardiac Function in a Pressure-Overload Model of Heart Failure. JACC: Basic to Translational Science, 5 (5). http://dx.doi.org/10.1016/j.jacbts.2020.03.007