Association between the luteinizing hormone/chorionic gonadotropin receptor (LHCGR) rs4073366 polymorphism and ovarian hyperstimulation syndrome during controlled ovarian hyperstimulation

Authors

Travis J. O'Brien, George Washington UniversityFollow
Mariah M. Kalmin, George Washington UniversityFollow
Arthur F. Harralson, Shenandoah UniversityFollow
Adam M. Clark, George Washington University
Ian Gindoff, George Washington University
Samuel J. Simmens, George Washington UniversityFollow
David Frankfurter, George Washington UniversityFollow
Paul Gindoff, George Washington University

Document Type

Journal Article

Publication Date

2013

Journal

Reproductive Biology and Endocrinology

Volume

Volume 11, Issue 1

Inclusive Pages

Article number 71

Abstract

Background

The aim of this study was to determine the relationship between a purported luteinizing hormone/chorionic gonadotropin (LHCGR) high function polymorphism (rs4539842/insLQ) and outcome to controlled ovarian hyperstimulation (COH).

Methods

This was a prospective study of 172 patients undergoing COH at the Fertility and IVF Center at GWU. DNA was isolated from blood samples and a region encompassing the insLQ polymorphism was sequenced. We also investigated a polymorphism (rs4073366 G > C) that was 142 bp frominsLQ. The association of the insLQ and rs4073366 alleles and outcome to COH (number of mature follicles, estradiol level on day of human chorionic gonadotropin (hCG) administration, the number of eggs retrieved and ovarian hyperstimulation syndrome (OHSS)) was determined.

Results

Increasing age and higher day 3 (basal) FSH levels were significantly associated with poorer response to COH. We found that both insLQ and rs4073366 were in linkage disequilibrium (LD) and no patients were homozygous for both recessive alleles (insLQ/insLQ; C/C). The insLQ variant was not significantly associated with any of the main outcomes to COH. Carrier status for the rs4073366 C variant was associated (P = 0.033) with an increased risk (OR 2.95, 95% CI = 1.09-7.96) of developing OHSS.

Conclusions

While age and day 3 FSH levels were predictive of outcome, we found no association betweeninsLQ and patient response to COH. Interestingly, rs4073366 C variant carrier status was associated with OHSS risk. To the best of our knowledge, this is the first report suggesting thatLHCGR genetic variation might function in patient risk for OHSS.

Comments

Reproduced with permission of BioMed Central Reproductive Biology & Endocrinology Journal

Creative Commons License

This work is licensed under a Creative Commons Attribution 3.0 License.

APA Citation

O'Brien, T.J. , Kalmin, M.M. , Harralson, A.F. , Clark, A.M. , Gindoff, I. , Simmens, S.J., Frankfurter, D., Gindoff, P. (2013). Association between the luteinizing hormone/chorionic gonadotropin receptor (LHCGR) rs4073366 polymorphism and ovarian hyperstimulation syndrome during controlled ovarian hyperstimulation. Reproductive Biology & Endocrinology, 11(1):71.

Peer Reviewed

1

Open Access

1