Medial prefrontal cortex in neurological diseases
Document Type
Journal Article
Publication Date
9-1-2019
Journal
Physiological Genomics
Volume
51
Issue
9
DOI
10.1152/physiolgenomics.00006.2019
Keywords
Cortical region; Medial prefrontal cortex; Neural circuit; Neurological disease; Pathophysiology
Abstract
The medial prefrontal cortex (mPFC) is a crucial cortical region that integrates information from numerous cortical and subcortical areas and converges updated information to output structures. It plays essential roles in the cognitive process, regulation of emotion, motivation, and sociability. Dysfunction of the mPFC has been found in various neurological and psychiatric disorders, such as depression, anxiety disorders, schizophrenia, autism spectrum disorders, Alzheimer’s disease, Parkinson’s disease, and addiction. In the present review, we summarize the preclinical and clinical studies to illustrate the role of the mPFC in these neurological diseases.
APA Citation
Xu, P., Chen, A., Li, Y., Xing, X., & Lu, H. (2019). Medial prefrontal cortex in neurological diseases. Physiological Genomics, 51 (9). http://dx.doi.org/10.1152/physiolgenomics.00006.2019