Title

Medial prefrontal cortex in neurological diseases

Document Type

Journal Article

Publication Date

9-1-2019

Journal

Physiological Genomics

Volume

51

Issue

9

DOI

10.1152/physiolgenomics.00006.2019

Keywords

Cortical region; Medial prefrontal cortex; Neural circuit; Neurological disease; Pathophysiology

Abstract

The medial prefrontal cortex (mPFC) is a crucial cortical region that integrates information from numerous cortical and subcortical areas and converges updated information to output structures. It plays essential roles in the cognitive process, regulation of emotion, motivation, and sociability. Dysfunction of the mPFC has been found in various neurological and psychiatric disorders, such as depression, anxiety disorders, schizophrenia, autism spectrum disorders, Alzheimer’s disease, Parkinson’s disease, and addiction. In the present review, we summarize the preclinical and clinical studies to illustrate the role of the mPFC in these neurological diseases.

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