Integrated omics endotyping of infants with respiratory syncytial virus bronchiolitis and risk of childhood asthma.
Asthma; Bronchiolitis, Viral; Female; Gene Expression; Genetic Predisposition to Disease; Hospitalization; Humans; Infant; Male; Metabolome; Microbiota; Prospective Studies; Respiratory Syncytial Virus Infections; Respiratory Syncytial Virus, Human; Respiratory System; Rhinovirus; Risk Factors; Transcriptome; United States
Respiratory syncytial virus (RSV) bronchiolitis is not only the leading cause of hospitalization in U.S. infants, but also a major risk factor for asthma development. While emerging evidence suggests clinical heterogeneity within RSV bronchiolitis, little is known about its biologically-distinct endotypes. Here, we integrated clinical, virus, airway microbiome (species-level), transcriptome, and metabolome data of 221 infants hospitalized with RSV bronchiolitis in a multicentre prospective cohort study. We identified four biologically- and clinically-meaningful endotypes: A) clinical
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Raita, Y., Pérez-Losada, M., Freishtat, R. J., Harmon, B., Mansbach, J., Piedra, P., Zhu, Z., Camargo, C., & Hasegawa, K. (2021). Integrated omics endotyping of infants with respiratory syncytial virus bronchiolitis and risk of childhood asthma.. Nat Commun, 12 (1). http://dx.doi.org/10.1038/s41467-021-23859-6
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