Integrated omics endotyping of infants with respiratory syncytial virus bronchiolitis and risk of childhood asthma.

Authors

Yoshihiko Raita
Marcos Pérez-Losada
Robert J. Freishtat, George Washington University
Brennan Harmon
Jonathan M Mansbach
Pedro A Piedra
Zhaozhong Zhu
Carlos A Camargo
Kohei Hasegawa

Document Type

Journal Article

Publication Date

6-14-2021

Journal

Nat Commun

Volume

12

Issue

1

DOI

10.1038/s41467-021-23859-6

Grant Information

CTSI FUNDED.

Keywords

Asthma; Bronchiolitis, Viral; Female; Gene Expression; Genetic Predisposition to Disease; Hospitalization; Humans; Infant; Male; Metabolome; Microbiota; Prospective Studies; Respiratory Syncytial Virus Infections; Respiratory Syncytial Virus, Human; Respiratory System; Rhinovirus; Risk Factors; Transcriptome; United States

Abstract

Respiratory syncytial virus (RSV) bronchiolitis is not only the leading cause of hospitalization in U.S. infants, but also a major risk factor for asthma development. While emerging evidence suggests clinical heterogeneity within RSV bronchiolitis, little is known about its biologically-distinct endotypes. Here, we integrated clinical, virus, airway microbiome (species-level), transcriptome, and metabolome data of 221 infants hospitalized with RSV bronchiolitis in a multicentre prospective cohort study. We identified four biologically- and clinically-meaningful endotypes: A) clinical

Comments

© The Author(s) 2021

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.

APA Citation

Raita, Y., Pérez-Losada, M., Freishtat, R. J., Harmon, B., Mansbach, J., Piedra, P., Zhu, Z., Camargo, C., & Hasegawa, K. (2021). Integrated omics endotyping of infants with respiratory syncytial virus bronchiolitis and risk of childhood asthma.. Nat Commun, 12 (1). http://dx.doi.org/10.1038/s41467-021-23859-6

Peer Reviewed

1

Open Access

1