Combined l-citrulline and tetrahydrobiopterin therapy improves NO signaling and ameliorates chronic hypoxia-induced pulmonary hypertension in newborn pigs.

Authors

Anna Dikalova
Judy L Aschner
Mark R Kaplowitz
Gary Cunningham, George Washington University
Marshall Summar, George Washington University
Candice D Fike

Document Type

Journal Article

Publication Date

4-1-2020

Journal

American Journal of Physiology: Lung Cellular and Molecular Physiology

Volume

318

Issue

4

Inclusive Pages

L762-L772

DOI

10.1152/ajplung.00280.2019

Keywords

Animals; Animals, Newborn; Arginine; Biopterin; Citrulline; Hypertension, Pulmonary; Hypoxia; Nitric Oxide; Nitric Oxide Synthase Type III; Pulmonary Artery; Signal Transduction; Swine; Vascular Resistance

Comments

Epub 2020 Feb 19

APA Citation

Dikalova, A., Aschner, J., Kaplowitz, M., Cunningham, G., Summar, M., & Fike, C. (2020). Combined l-citrulline and tetrahydrobiopterin therapy improves NO signaling and ameliorates chronic hypoxia-induced pulmonary hypertension in newborn pigs.. American Journal of Physiology: Lung Cellular and Molecular Physiology, 318 (4). http://dx.doi.org/10.1152/ajplung.00280.2019

Peer Reviewed

1