Document Type
Journal Article
Publication Date
1-1-2016
Journal
PLoS One
Volume
11
Issue
4
Inclusive Pages
Article Number e0153244
DOI
10.1371/journal.pone.0153244
Abstract
Sickle cell anemia (SCA) is an inherited hemolytic anemia with compensatory reticulocytosis. Recent studies have shown that increased levels of reticulocytosis during infancy are associated with increased hospitalizations for SCA sequelae as well as cerebrovascular pathologies. In this study, absolute reticulocyte counts (ARC) measured prior to transfusion were analysed among a cohort of 29 pediatric SCA patients receiving chronic transfusion therapy (CTT) for primary and secondary stroke prevention. A cross-sectional flow cytometric analysis of the reticulocyte phenotype was also performed. Mean duration of CTT was 3.1 ± 2.6 years. Fifteen subjects with magnetic resonance angiography (MRA) -vasculopathy had significantly higher mean ARC prior to initiating CTT compared to 14 subjects without MRA-vasculopathy (427.6 ± 109.0 K/μl vs. 324.8 ± 109.2 K/μl, p
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
APA Citation
Kaushal, M., Byrnes, C., Khademian, Z., Duncan, N., Luban, N. L., Miller, J., Fasano, R., & Meier, E. R. (2016). Examination of Reticulocytosis among Chronically Transfused Children with Sickle Cell Anemia.. PLoS One, 11 (4). http://dx.doi.org/10.1371/journal.pone.0153244
Peer Reviewed
1
Open Access
1
Comments
Reproduced with permission of PLoS ONE.