Document Type
Journal Article
Publication Date
5-5-2015
Journal
Journal of Infectious Diseases
DOI
10.1093/infdis/jiv245
Abstract
Prolonged treatment of an immunocompromised child with oseltamivir and zanamivir for A(H1N1)pdm09 virus infection led to the emergence of viruses carrying H275Y and/or E119G in the neuraminidase. When phenotypically evaluated by neuraminidase inhibition, the dual H275Y-E119G substitution caused highly reduced inhibition by four neuraminidase inhibitors including oseltamivir, zanamivir, peramivir and laninamivir.
Creative Commons License
This work is free of known copyright restrictions.
APA Citation
Epub ahead of print
Peer Reviewed
1
Open Access
1
Supplementary Data.docx (15 kB)
Supplementary Data
Supplementary Data
Comments
Published by Oxford University Press on behalf of the Infectious Diseases Society of America 2015. This work is written by (a) US Government employee(s) and is in the public domain in the US.