Barrett's esophagus: Histology and immunohistology

Document Type

Journal Article

Publication Date

1-1-2011

Journal

Annals of the New York Academy of Sciences

Volume

1232

Issue

1

DOI

10.1111/j.1749-6632.2011.06046.x

Keywords

ACG guidelines; Adenocarcinoma; BSG guidelines; Cardiac mucosa; CDX2; Cytokeratin 20; Cytokeratin 7; Das-1; Epithelium; Esophageal glands; Esophageal microanatomy; Four-quadrant biopsies; Gastroesophageal junction; Goblet cells; Immunohistochemistry; Intestinal metaplasia; Montreal Working Group; MUC2; Oxyntic cells; Prague criteria; Pseudogoblet cells; Reflux esophagitis; Submucosal glands; Villin

Abstract

The following on histology and immunohistology of Barrett's esophagus (BE) includes commentaries on the various difficulties remaining in reaching a consensus on the definition of BE; the difficulties in the characterization of intestinal and cardiac mucosa, and in the role of submucosal glands in the development of BE; the importance of a new monoclonal antibody to recognize esophageal intestinal mucosa; the importance of pseudo goblet cells; the best techniques for the endoscopic detection of Barrett's epithelium; and the biomarkers for identification of patients predisposed to the development of BE. © 2011 New York Academy of Sciences.

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