Herbal extracts as hepatoprotectants against acetaminophen hepatotoxicity

Document Type

Journal Article

Publication Date

5-21-2010

Journal

World Journal of Gastroenterology

Volume

16

Issue

19

DOI

10.3748/wjg.v16.i19.2448

Keywords

Acetaminophen; Drug hepatotoxicity; Herbal extracts; N-acetylcysteine

Abstract

Many plant-derived natural products have the potential to be hepatoprotective and therefore can be used to treat acute and chronic liver diseases. The challenge is to identify the most promising compounds and evaluate their protective mechanism. In a recently published article, Wang et al evaluated extracts of the plant Gentiana manshiurica Kitagawa (GM) in a model of acetaminophen hepatotoxicity. The authors concluded that GM is hepatoprotective against acetaminophen-induced liver injury due to its antioxidant properties and anti-apoptotic capacity. We would like to discuss the limitations of this experimental approach and question the conclusion based on the data presented in this manuscript and the published literature. © 2010 Baishideng.

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