Argininosuccinate synthetase as a plasma biomarker of liver injury after acetaminophen overdose in rodents and humans
Document Type
Journal Article
Publication Date
1-1-2014
Journal
Biomarkers
Volume
19
Issue
3
DOI
10.3109/1354750X.2014.897757
Keywords
Acetaminophen; Diagnosis; Hepatotoxicity; Mitochondria; Prognosis
Abstract
Context: New biomarkers are needed in acetaminophen (APAP) hepatotoxicity. Plasma argininosuccinate synthetase (ASS) is a promising candidate. Objective: Characterize ASS in APAP hepatotoxicity. Methods: ASS was measured in plasma from rodents and humans with APAP hepatotoxicity. Results: In mice, ASS increased before injury, peaked before alanine aminotransferase (ALT) and decreased rapidly. Fischer rats had a greater increase in ASS relative to ALT. Patients with abnormal liver test results had very high ASS compared to controls. ASS appeared to increase early in some patients, and declined rapidly in all. Conclusions: ASS may be a useful biomarker of acute cell death in APAP hepatotoxicity. © 2014 Informa UK Ltd. All rights reserved: reproduction in whole or part not permitted.
APA Citation
McGill, M., Cao, M., Svetlov, A., Sharpe, M., Williams, C., Curry, S., Farhood, A., Jaeschke, H., & Svetlov, S. (2014). Argininosuccinate synthetase as a plasma biomarker of liver injury after acetaminophen overdose in rodents and humans. Biomarkers, 19 (3). http://dx.doi.org/10.3109/1354750X.2014.897757