Molecular Biomarkers for the Evaluation of Colorectal Cancer: Guideline From the American Society for Clinical Pathology, College of American Pathologists, Association for Molecular Pathology, and American Society of Clinical Oncology
Document Type
Journal Article
Publication Date
3-1-2017
Journal
Journal of Molecular Diagnostics
Volume
19
Issue
2
DOI
10.1016/j.jmoldx.2016.11.001
Abstract
© 2017 American Society for Clinical Pathology, College of American Pathologists, Association for Molecular Pathology, American Society for Clinical Oncology, and American Society for Investigative Pathology Objectives: To develop evidence-based guideline recommendations through a systematic review of the literature to establish standard molecular biomarker testing of colorectal cancer (CRC) tissues to guide epidermal growth factor receptor (EGFR) therapies and conventional chemotherapy regimens. Methods: The American Society for Clinical Pathology, College of American Pathologists, Association for Molecular Pathology, and American Society of Clinical Oncology convened an expert panel to develop an evidence-based guideline to establish standard molecular biomarker testing and guide therapies for patients with CRC. A comprehensive literature search that included more than 4,000 articles was conducted. Results: Twenty-one guideline statements were established. Conclusions: Evidence supports mutational testing for EGFR signaling pathway genes, since they provide clinically actionable information as negative predictors of benefit to anti-EGFR monoclonal antibody therapies for targeted therapy of CRC. Mutations in several of the biomarkers have clear prognostic value. Laboratory approaches to operationalize CRC molecular testing are presented. Key Words: Molecular diagnostics; Gastrointestinal; Histology; Genetics; Oncology.
APA Citation
Sepulveda, A., Hamilton, S., Allegra, C., Grody, W., Cushman-Vokoun, A., Funkhouser, W., Kopetz, S., Lieu, C., Lindor, N., Minsky, B., Monzon, F., Sargent, D., Singh, V., Willis, J., Clark, J., Colasacco, C., Rumble, R., Temple-Smolkin, R., Ventura, C., & Nowak, J. (2017). Molecular Biomarkers for the Evaluation of Colorectal Cancer: Guideline From the American Society for Clinical Pathology, College of American Pathologists, Association for Molecular Pathology, and American Society of Clinical Oncology. Journal of Molecular Diagnostics, 19 (2). http://dx.doi.org/10.1016/j.jmoldx.2016.11.001