Document Type
Journal Article
Publication Date
2013
Journal
Open Journal of Hematology
Volume
Volume 4
Abstract
B lymphoblastic leukemia (B-ALL) may be associated with recurrent cytogenetic and molecular abnormalities. We describe the fourth-known case of B-ALL associated with the t(8;22)(p11.2q11.2) – a translocation seen more frequently in T lymphoblastic leukemia and acute myelogenous leukemia. This patient’s leukemia involves a combination of additional cytogenetic anomalies not yet described in the literature, including del(11)(q13q23), add(9)(p22), and monosomy 7. Given the role in B cell differentiation of genes in the affected regions, including MEN1 (11q13), ATM (11q22), ETS1(11q23), MLL (11q23), AF9 (9p22), and IKZ-F1 (7p12), this case may provide further insight into B cell leukemogenesis associated with the t(8;22). Deletion or mutation of these genes may be critical in targeting the B cell population, and this cytogenetic profile of a B-ALL suggests additional gene targets for diagnostic and therapeutic consideration.
Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.
APA Citation
Serdy, K.M., Khoury, S.R., DePalma, L (2013). B cell acute lymphoblastic leukemia associated with t(8;22)(p11.2q11.2): Role of additional cytogenic anomalies. Open Journal of Hematology, 4.
Open Access
1
Comments
Reproduced with permission of Ross Science Publishers.