The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution
Document Type
Journal Article
Publication Date
4-8-2019
Journal
Developmental Cell
Volume
49
Issue
1
DOI
10.1016/j.devcel.2019.03.001
Abstract
Single-cell gene expression analyses of mammalian tissues have uncovered profound stage-specific molecular regulatory phenomena that have changed the understanding of unique cell types and signaling pathways critical for lineage determination, morphogenesis, and growth. We discuss here the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium to provide single-cell profiles and spatial characterization of gene expression across human tissues and organs. Such data will complement adult and developmentally focused HCA projects to provide a rich cytogenomic framework for understanding not only pediatric health and disease but also environmental and genetic impacts across the human lifespan. We discuss the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium. Such data will complement adult and developmentally focused HCA projects to provide a rich cytogenomic framework for understanding not only pediatric health and disease but also environmental and genetic impacts across the human lifespan.
APA Citation
Taylor, D., Aronow, B., Tan, K., Bernt, K., Salomonis, N., Greene, C., Frolova, A., Henrickson, S., Wells, A., Pei, L., Jaiswal, J., Whitsett, J., Hamilton, K., MacParland, S., Kelsen, J., Heuckeroth, R., Potter, S., Vella, L., Terry, N., Ghanem, L., Kennedy, B., Helbig, I., Sullivan, K., Castelo-Soccio, L., Kreigstein, A., Herse, F., Nawijn, M., Koppelman, G., Haendel, M., Harris, N., Rokita, J., & Zhang, Y. (2019). The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution. Developmental Cell, 49 (1). http://dx.doi.org/10.1016/j.devcel.2019.03.001