Title

K–STIMULATED ACETYLCHOLINE RELEASE: INHIBITION BY SEVERAL BARBITURATES AND CHLORAL HYDRATE BUT NOT BY ETHANOL, CHLORDIAZEPOXIDE OR 11‐OH‐Δ9‐TETRAHYDROCANNABINOL

Document Type

Journal Article

Publication Date

1-1-1979

Journal

Journal of Neurochemistry

Volume

32

Issue

3

DOI

10.1111/j.1471-4159.1979.tb04578.x

Abstract

Abstract— Thiamylal, methohexital, secobarbital, amobarbital, pentobarbital, phenobarbital and barbital, and also chloral hydrate inhibited K‐stimuiated acetylcholine (ACh) release from rat midbrain slices in a dose related manner. The concentrations required for 50% inhibition were related to the lipid partition coefficient. None of the barbiturates nor chloral hydrate inhibited unstimulated ACh release. Ethanol, chlordiazepoxide and 11‐OH‐Δ9‐tetrahydrocannabinol were without effect on both unstimulated and stimulated ACh release. The results are discussed in terms of other effects of these drugs on the cholinergic system. Copyright © 1979, Wiley Blackwell. All rights reserved

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