K–STIMULATED ACETYLCHOLINE RELEASE: INHIBITION BY SEVERAL BARBITURATES AND CHLORAL HYDRATE BUT NOT BY ETHANOL, CHLORDIAZEPOXIDE OR 11‐OH‐Δ9‐TETRAHYDROCANNABINOL
Document Type
Journal Article
Publication Date
1-1-1979
Journal
Journal of Neurochemistry
Volume
32
Issue
3
DOI
10.1111/j.1471-4159.1979.tb04578.x
Abstract
Abstract— Thiamylal, methohexital, secobarbital, amobarbital, pentobarbital, phenobarbital and barbital, and also chloral hydrate inhibited K‐stimuiated acetylcholine (ACh) release from rat midbrain slices in a dose related manner. The concentrations required for 50% inhibition were related to the lipid partition coefficient. None of the barbiturates nor chloral hydrate inhibited unstimulated ACh release. Ethanol, chlordiazepoxide and 11‐OH‐Δ9‐tetrahydrocannabinol were without effect on both unstimulated and stimulated ACh release. The results are discussed in terms of other effects of these drugs on the cholinergic system. Copyright © 1979, Wiley Blackwell. All rights reserved
APA Citation
Richter, J., & Werling, L. (1979). K–STIMULATED ACETYLCHOLINE RELEASE: INHIBITION BY SEVERAL BARBITURATES AND CHLORAL HYDRATE BUT NOT BY ETHANOL, CHLORDIAZEPOXIDE OR 11‐OH‐Δ9‐TETRAHYDROCANNABINOL. Journal of Neurochemistry, 32 (3). http://dx.doi.org/10.1111/j.1471-4159.1979.tb04578.x