Effects of prior exposure to morphine on the opioid inhibition of the stimulated release of [3H]norepinephrine from guinea pig cortex slices.

Authors

L. L. Werling, Uniformed Services University of the Health Sciences
S. R. Brown, Uniformed Services University of the Health Sciences
B. M. Cox, Uniformed Services University of the Health Sciences

Document Type

Journal Article

Publication Date

1-1-1986

Journal

NIDA research monograph

Volume

75

Abstract

The potassium stimulated release of [3H]norepinephrine ([3H]NE) from terminal fields of locus coeruleus projections can be inhibited in a dose-dependent manner by mu and kappa selective opioids. Chronic exposure to morphine for six days decreases the maximum achievable depression by the mu selective agonist Tyr-D-Ala2-Gly-Me(Phe)-Gly-ol (DAGO), but has no effect on the degree of inhibition produced by the kappa selective opioid U50,488H.

APA Citation

Werling, L., Brown, S., & Cox, B. (1986). Effects of prior exposure to morphine on the opioid inhibition of the stimulated release of [3H]norepinephrine from guinea pig cortex slices.. NIDA research monograph, 75 (). Retrieved from https://hsrc.himmelfarb.gwu.edu/smhs_path_facpubs/1410