The complete genome sequence of the gastric pathogen Helicobacter pylori

Authors

Jean F. Tomb, J. Craig Venter Institute
Owen White, J. Craig Venter Institute
Anthony R. Kerlavage, J. Craig Venter Institute
Rebecca A. Clayton, J. Craig Venter Institute
Granger G. Sutton, J. Craig Venter Institute
Robert D. Fleischmann, J. Craig Venter Institute
Karen A. Ketchum, J. Craig Venter Institute
Hans Peter Klenk, J. Craig Venter Institute
Steven Gill, J. Craig Venter Institute
Brian A. Dougherty, J. Craig Venter Institute
Karen Nelson, J. Craig Venter Institute
John Quackenbush, J. Craig Venter Institute
Lixin Zhou, J. Craig Venter Institute
Ewen F. Kirkness, J. Craig Venter Institute
Scott Peterson, J. Craig Venter Institute
Brendan Loftus, J. Craig Venter Institute
Delwood Richardson, J. Craig Venter Institute
Robert Dodson, J. Craig Venter Institute
Hanif G. Khalak, J. Craig Venter Institute
Anna Glodek, J. Craig Venter Institute
Keith McKenney, J. Craig Venter Institute
Lisa M. Fitzegerald, J. Craig Venter Institute
Norman Lee, J. Craig Venter Institute
Mark D. Adams, J. Craig Venter Institute
Erin K. Hickey, J. Craig Venter Institute
Douglas E. Berg, Washington University in St. Louis
Jeanine D. Gocayne, J. Craig Venter Institute
Teresa R. Utterback, J. Craig Venter Institute
Jeremy D. Peterson, J. Craig Venter Institute
Jenny M. Kelley, J. Craig Venter Institute
Matthew D. Cotton, J. Craig Venter Institute
Janice M. Weidman, J. Craig Venter Institute
Claire Fujii, J. Craig Venter Institute

Document Type

Journal Article

Publication Date

8-25-1997

Journal

Nature

Volume

388

Issue

6642

DOI

10.1038/41483

Abstract

Helicobacter pylori, strain 26695, has circular genome of 1,667,867 base pairs and 1,590 predicted coding sequences. Sequence analysis indicates that H. pylori has well-developed systems for motility, for scavenging iron, and for DNA restriction and modification. Many putative adhesins, lipoproteins and other outer membrane proteins were identified, underscoring the potential complexity of host-pathogen interaction. Based on the large number of sequence-related genes encoding outer membrane proteins and the presence of homopolymeric tracts and dinucleotide repeats in coding sequences, H. pylori, like several other mucosal pathogens, probably uses recombination and slipped-strand mispairing within repeats as mechanisms for antigenio variation and adaptive evolution. Consistent with its restricted niche, H. pylori has a few regulatory networks, and a limited metabolic repertoire and biosynthetic capacity. Its survival in acid conditions depends, in part, on its ability to establish a positive inside-membrane potential in low pH.

APA Citation

Tomb, J., White, O., Kerlavage, A., Clayton, R., Sutton, G., Fleischmann, R., Ketchum, K., Klenk, H., Gill, S., Dougherty, B., Nelson, K., Quackenbush, J., Zhou, L., Kirkness, E., Peterson, S., Loftus, B., Richardson, D., Dodson, R., Khalak, H., Glodek, A., McKenney, K., Fitzegerald, L., Lee, N., Adams, M., Hickey, E., Berg, D., Gocayne, J., Utterback, T., Peterson, J., Kelley, J., Cotton, M., Weidman, J., & Fujii, C. (1997). The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature, 388 (6642). http://dx.doi.org/10.1038/41483