Role of Alternative Splicing in Prostate Cancer Aggressiveness and Drug Resistance in African Americans

Document Type

Journal Article

Publication Date

1-1-2019

Journal

Advances in Experimental Medicine and Biology

Volume

1164

DOI

10.1007/978-3-030-22254-3_10

Keywords

Alternative splicing; Cancer disparities; Drug resistance; Prostate cancer

Abstract

© 2019, Springer Nature Switzerland AG. Alternative splicing, the process of removing introns and joining exons of pre-mRNA, is critical for growth, development, tissue homeostasis, and species diversity. Dysregulation of alternative splicing can initiate and drive disease. Aberrant alternative splicing has been shown to promote the “hallmarks of cancer” in both hematological and solid cancers. Of interest, recent work has focused on the role of alternative splicing in prostate cancer and prostate cancer health disparities. We will provide a review of prostate cancer health disparities involving the African American population, alternative RNA splicing, and alternative splicing in prostate cancer. Lastly, we will summarize our work on differential alternative splicing in prostate cancer disparities and its implications for disparate health outcomes and therapeutic targets.

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