Role of Alternative Splicing in Prostate Cancer Aggressiveness and Drug Resistance in African Americans
Document Type
Journal Article
Publication Date
1-1-2019
Journal
Advances in Experimental Medicine and Biology
Volume
1164
DOI
10.1007/978-3-030-22254-3_10
Keywords
Alternative splicing; Cancer disparities; Drug resistance; Prostate cancer
Abstract
© 2019, Springer Nature Switzerland AG. Alternative splicing, the process of removing introns and joining exons of pre-mRNA, is critical for growth, development, tissue homeostasis, and species diversity. Dysregulation of alternative splicing can initiate and drive disease. Aberrant alternative splicing has been shown to promote the “hallmarks of cancer” in both hematological and solid cancers. Of interest, recent work has focused on the role of alternative splicing in prostate cancer and prostate cancer health disparities. We will provide a review of prostate cancer health disparities involving the African American population, alternative RNA splicing, and alternative splicing in prostate cancer. Lastly, we will summarize our work on differential alternative splicing in prostate cancer disparities and its implications for disparate health outcomes and therapeutic targets.
APA Citation
Olender, J., & Lee, N. (2019). Role of Alternative Splicing in Prostate Cancer Aggressiveness and Drug Resistance in African Americans. Advances in Experimental Medicine and Biology, 1164 (). http://dx.doi.org/10.1007/978-3-030-22254-3_10