Title

Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding

Document Type

Journal Article

Publication Date

1-1-2014

Journal

Nature Neuroscience

Volume

17

Issue

7

DOI

10.1038/nn.3725

Abstract

We found that leptin receptors were expressed in hypothalamic astrocytes and that their conditional deletion led to altered glial morphology and synaptic inputs onto hypothalamic neurons involved in feeding control. Leptin-regulated feeding was diminished, whereas feeding after fasting or ghrelin administration was elevated in mice with astrocyte-specific leptin receptor deficiency. These data reveal an active role of glial cells in hypothalamic synaptic remodeling and control of feeding by leptin. © 2014 Nature America, Inc. All rights reserved.

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