Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding
Document Type
Journal Article
Publication Date
1-1-2014
Journal
Nature Neuroscience
Volume
17
Issue
7
DOI
10.1038/nn.3725
Abstract
We found that leptin receptors were expressed in hypothalamic astrocytes and that their conditional deletion led to altered glial morphology and synaptic inputs onto hypothalamic neurons involved in feeding control. Leptin-regulated feeding was diminished, whereas feeding after fasting or ghrelin administration was elevated in mice with astrocyte-specific leptin receptor deficiency. These data reveal an active role of glial cells in hypothalamic synaptic remodeling and control of feeding by leptin. © 2014 Nature America, Inc. All rights reserved.
APA Citation
Kim, J., Suyama, S., Koch, M., Jin, S., Argente-Arizon, P., Argente, J., Liu, Z., Zimmer, M., Jeong, J., Szigeti-Buck, K., Gao, Y., Garcia-Caceres, C., Yi, C., Salmaso, N., Vaccarino, F., Chowen, J., Diano, S., Dietrich, M., Tschöp, M., & Horvath, T. (2014). Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding. Nature Neuroscience, 17 (7). http://dx.doi.org/10.1038/nn.3725