Hyperalimentation-associated jaundice: An example of a serum factor inducing cholestasis in rats
Document Type
Journal Article
Publication Date
1-1-1985
Journal
American Journal of Clinical Nutrition
Volume
41
Issue
1
DOI
10.1093/ajcn/41.1.61
Abstract
A patient receiving total parenteral nutrition (TPN) at home following emergency resection of the small intestine was studied over a two year interval. Cholestatic jaundice developed after 6 months. A factor in serum was found to produce cholestatic changes in the bile flow of rats on intravenous infusion. Normal human serum and saline infusion did not produce this cholestasis. Endotoxin infusion in the rat produced a similar impairment in bile flow. The hypothesis was proposed that endotoxin might be an occult factor contributing to cholestasis in this case. An antiserum prepared to an endotoxin isolated from a sequestered E. coli infection in this patient, ameliorated the cholestatic effects of the patients' serum in rats. The possible role of endotoxin in the cholestasis of the TPN-induced jaundice in this patient is presented and discussed.
APA Citation
Latham, P., Menkes, E., Phillips, M., & Jeejeebhoy, K. (1985). Hyperalimentation-associated jaundice: An example of a serum factor inducing cholestasis in rats. American Journal of Clinical Nutrition, 41 (1). http://dx.doi.org/10.1093/ajcn/41.1.61