Chronic liver diseases following community-acquired non-A, non-B hepatitis
American Journal of Clinical Pathology
Chronic non-A, non-B hepatitis occurring in an urban American population was identified in 23 patients followed for more than 6 months after the onset of acute hepatitis. Eight of the 23 patients subsequently developed normal aminotransferase levels a mean of 12.3 months after the onset of hepatitis. Liver biopsies were obtained from 9 of the remaining 15 patients. Eight biopsies revealed abnormalities consistent with chronic persistent hepatitis. One revealed chronic active hepatitis. The probable source of hepatitis included blood transfusions in 4%, intravenous drugs in 43%, personal contact in 4%, and no known source in 48%. Normalization of aminotransferase activity could not be predicted by initial symptoms, physical findings, or laboratory values. This study suggests that the chronic liver disease following community-acquired non-A, non-B hepatitis is frequent and may have a benign course.
Mathieson, R., Sampliner, R., & Latham, P. (1986). Chronic liver diseases following community-acquired non-A, non-B hepatitis. American Journal of Clinical Pathology, 85 (3). http://dx.doi.org/10.1093/ajcp/85.3.353