Chronic liver diseases following community-acquired non-A, non-B hepatitis

Document Type

Journal Article

Publication Date

1-1-1986

Journal

American Journal of Clinical Pathology

Volume

85

Issue

3

DOI

10.1093/ajcp/85.3.353

Abstract

Chronic non-A, non-B hepatitis occurring in an urban American population was identified in 23 patients followed for more than 6 months after the onset of acute hepatitis. Eight of the 23 patients subsequently developed normal aminotransferase levels a mean of 12.3 months after the onset of hepatitis. Liver biopsies were obtained from 9 of the remaining 15 patients. Eight biopsies revealed abnormalities consistent with chronic persistent hepatitis. One revealed chronic active hepatitis. The probable source of hepatitis included blood transfusions in 4%, intravenous drugs in 43%, personal contact in 4%, and no known source in 48%. Normalization of aminotransferase activity could not be predicted by initial symptoms, physical findings, or laboratory values. This study suggests that the chronic liver disease following community-acquired non-A, non-B hepatitis is frequent and may have a benign course.

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