Infection of T but not B lymphocytes by cytomegalovirus in lymph node: An immunophenotypic study
Document Type
Journal Article
Publication Date
1-1-1991
Journal
American Journal of Surgical Pathology
Volume
15
Issue
1
DOI
10.1097/00000478-199101000-00009
Keywords
Cytomegalovirus; Lymph nodes; T cells
Abstract
A 45-year-old black man presented with fever, night sweats, weight loss, and cervical lymphadenopathy. Biopsy of an enlarged node showed partial effacement of the nodal architecture by numerous cells with typical cytomegalovirus (CMV) inclusions. These were also seen by electron microscopy. CMV titers were not elevated, and he tested negative for HIV. An immunophenotypic study done on both paraffin-embedded and frozen tissue showed that the infected cells were of T-lymphocyte phenotype. These cells were remarkable for the lack of HLA-DR and IL-2R antigens, which were expressed by numerous neighboring apparently uninfected cells. The lack of HLA-DR and IL-2R expression by CMV-infected T lymphocytes may be one of the mechanisms by which CMV causes immunosuppression.
APA Citation
Younes, M., Podesta, A., Helie, M., & Buckley, P. (1991). Infection of T but not B lymphocytes by cytomegalovirus in lymph node: An immunophenotypic study. American Journal of Surgical Pathology, 15 (1). http://dx.doi.org/10.1097/00000478-199101000-00009