Title

Is adrenomedullin a causal agent in some cases of type 2 diabetes?

Document Type

Journal Article

Publication Date

12-1-1999

Journal

Peptides

Volume

20

Issue

12

DOI

10.1016/S0196-9781(99)00158-8

Keywords

Adrenomedullin; Diabetic rat model; Gestational diabetes; Glucose tolerance; Glycemia regulation; Radioimmunoassay

Abstract

The study of two populations with a recent onset of type 2 diabetes showed that a subset of the patients had higher levels of adrenomedullin (AM) than the rest of the diabetics. In this subset, physiological elevations of AM might have triggered the disease in predisposed individuals. Diabetics showed higher levels of AM than healthy controls. In addition, glycemia was measured in diabetic rats after injection of saline, AM, or antiAM antibody. AM elevated glycemia, whereas the antibody reduced circulating glucose to normal. These results suggest that manipulation of AM levels could represent a new approach in the management of diabetes for the appropriate individuals.

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