Is adrenomedullin a causal agent in some cases of type 2 diabetes?
Document Type
Journal Article
Publication Date
12-1-1999
Journal
Peptides
Volume
20
Issue
12
DOI
10.1016/S0196-9781(99)00158-8
Keywords
Adrenomedullin; Diabetic rat model; Gestational diabetes; Glucose tolerance; Glycemia regulation; Radioimmunoassay
Abstract
The study of two populations with a recent onset of type 2 diabetes showed that a subset of the patients had higher levels of adrenomedullin (AM) than the rest of the diabetics. In this subset, physiological elevations of AM might have triggered the disease in predisposed individuals. Diabetics showed higher levels of AM than healthy controls. In addition, glycemia was measured in diabetic rats after injection of saline, AM, or antiAM antibody. AM elevated glycemia, whereas the antibody reduced circulating glucose to normal. These results suggest that manipulation of AM levels could represent a new approach in the management of diabetes for the appropriate individuals.
APA Citation
Martínez, A., Elsasser, T., Bhathena, S., Pío, R., Buchanan, T., Macri, C., & Cuttitta, F. (1999). Is adrenomedullin a causal agent in some cases of type 2 diabetes?. Peptides, 20 (12). http://dx.doi.org/10.1016/S0196-9781(99)00158-8