The association of maternal hypertensive disorders with neonatal congenital heart disease: analysis of a United States cohort

Document Type

Journal Article

Publication Date

11-1-2020

Journal

Journal of Perinatology

Volume

40

Issue

11

DOI

10.1038/s41372-020-00795-9

Abstract

© 2020, The Author(s), under exclusive licence to Springer Nature America, Inc. Objective: To examine the association of any type of maternal hypertensive disorders of pregnancy (HDP) and neonatal congenital heart diseases (CHD). Study design: We compared the prevalence of CHD between neonates born to mothers with HDP to those delivered to mothers without HDP among 24,525,889 hospital records of living infants, from a national database. We controlled for multiple confounding factors by using multiple logistic regression analysis. Results: Infants delivered to mothers with HDP had higher prevalence of CHD compared to infants born to mothers without HDP [5.20% vs. 1.47%; aOR: 2.51(2.38–2.64), p < 0.001]. Maternal diabetes was more frequent among infants born to mothers with HDP and was independently associated with CHD [aOR 5.14 (5.04–5.23), p < 0.001]. Conclusion: Infants born to mothers with hypertension had almost a threefold increase in CHD compared with those born to mothers without hypertension. Further studies are needed to investigate the underlying mechanism and direction of this association.

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