Lichen Sclerosus: An autoimmunopathogenic and genomic enigma with emerging genetic and immune targets.
Document Type
Journal Article
Publication Date
1-1-2019
Journal
Int J Biol Sci
Volume
15
Issue
7
DOI
10.7150/ijbs.34613
Abstract
Lichen sclerosus (LS) is an inflammatory dermatosis with a predilection for anogenital skin. Developing lesions lead to vulvar pain and sexual dysfunction, with a significant loss of structural anatomical architecture, sclerosis, and increased risk of malignancy. Onset may occur at any age in both sexes, but typically affects more females than males, presenting in a bimodal fashion among pre-pubertal children and middle-aged adults. A definitive cure remains elusive as the exact pathogenesis of LS remains unknown. A general review of LS, histologic challenges, along with amounting support for LS as an autoimmune disease with preference for a T
APA Citation
Tran, D., Tan, X., Macri, C., Goldstein, A., & Fu, S. (2019). Lichen Sclerosus: An autoimmunopathogenic and genomic enigma with emerging genetic and immune targets.. Int J Biol Sci, 15 (7). http://dx.doi.org/10.7150/ijbs.34613
Peer Reviewed
1
Open Access
1
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