Infantile spasms are the defining seizures of West syndrome, a severe form of early life epilepsy with poorly-understood pathophysiology. We present a novel comparative analysis of infants with spasms versus other seizure-types and identify clinical, etiological, and molecular-genetic factors preferentially predisposing to spasms. We compared ages, clinical etiologies, and associated-genes between spasms and non-spasms groups in a multicenter cohort of 509 infants (
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Berg, A., Chakravorty, S., Koh, S., Grinspan, Z., Shellhaas, R., Gaillard, W., & +several additional authors (2018). Why West? Comparisons of clinical, genetic and molecular features of infants with and without spasms.. PLoS One, 13 (3). http://dx.doi.org/10.1371/journal.pone.0193599