Cerebral pressure passivity in newborns with encephalopathy undergoing therapeutic hypothermia

Authors

Rathinaswamy B. Govindan, George Washington UniversityFollow
An Nguyen Massaro, George Washington UniversityFollow
Nickie N. Andescavage, Children's National Medical CenterFollow
Taeun Chang, George Washington University
Adre J. Du Plessis, George Washington UniversityFollow

Document Type

Journal Article

Publication Date

2014

Journal

Frontiers in Human Neuroscience

Volume

Volume 8

Inclusive Pages

Article number 266

Abstract

We extended our recent modification of the power spectral estimation approach to quantify spectral coherence. We tested both the standard and the modified approaches on simulated data, which showed that the modified approach was highly specific and sensitive to the coupling introduced in the simulation while the standard approach lacked these features. We also applied the modified and standard approaches to quantify the pressure passivity in 4 infants receiving therapeutic hypothermia. This was done by measuring the coupling between continuous cerebral hemoglobin differences and mean arterial blood pressure. Our results showed that the modified approach identified a lower pressure passivity index (PPI, percent time the coherence was above a predefined threshold) than the standard approach (P = 0.0027).

Comments

Reproduced with permission of Frontiers in Human Neuroscience.

Creative Commons License

This work is licensed under a Creative Commons Attribution 3.0 License.

APA Citation

Govindan, R.B., Massaro, A.N., Andescavage, N.N., Chang, T., du Plessis, A.J. (2014). Cerebral pressure passivity in newborns with encephalopathy undergoing therapeutic hypothermia. Frontiers in Human Neuroscience.

Peer Reviewed

1

Open Access

1