Lichen Sclerosus: An autoimmunopathogenic and genomic enigma with emerging genetic and immune targets.
Int J Biol Sci
Lichen sclerosus (LS) is an inflammatory dermatosis with a predilection for anogenital skin. Developing lesions lead to vulvar pain and sexual dysfunction, with a significant loss of structural anatomical architecture, sclerosis, and increased risk of malignancy. Onset may occur at any age in both sexes, but typically affects more females than males, presenting in a bimodal fashion among pre-pubertal children and middle-aged adults. A definitive cure remains elusive as the exact pathogenesis of LS remains unknown. A general review of LS, histologic challenges, along with amounting support for LS as an autoimmune disease with preference for a T
Tran, D., Tan, X., Macri, C., Goldstein, A., & Fu, S. (2019). Lichen Sclerosus: An autoimmunopathogenic and genomic enigma with emerging genetic and immune targets.. Int J Biol Sci, 15 (7). http://dx.doi.org/10.7150/ijbs.34613