Document Type
Journal Article
Publication Date
10-18-2016
Journal
Immunity
Volume
45
Issue
4
Inclusive Pages
917-930
DOI
10.1016/j.immuni.2016.09.015
Abstract
CD8(+) T cell recognition of virus-infected cells is characteristically restricted by major histocompatibility complex (MHC) class I, although rare examples of MHC class II restriction have been reported in Cd4-deficient mice and a macaque SIV vaccine trial using a recombinant cytomegalovirus vector. Here, we demonstrate the presence of human leukocyte antigen (HLA) class II-restricted CD8(+) T cell responses with antiviral properties in a small subset of HIV-infected individuals. In these individuals, T cell receptor β (TCRβ) analysis revealed that class II-restricted CD8(+) T cells underwent clonal expansion and mediated killing of HIV-infected cells. In one case, these cells comprised 12% of circulating CD8(+) T cells, and TCRα analysis revealed two distinct co-expressed TCRα chains, with only one contributing to binding of the class II HLA-peptide complex. These data indicate that class II-restricted CD8(+) T cell responses can exist in a chronic human viral infection, and may contribute to immune control.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
APA Citation
Ranasinghe, S., Lamothe, P., Soghoian, D., Kazer, S., Cole, M., Shalek, A., Yosef, N., Jones, R. B., Donaghey, F., Nwonu, C., Jani, P., Clayton, G., Crawford, F., White, J., Montoya, A., Power, K., Allen, T., Streeck, H., Kaufmann, D., Picker, L., Kappler, J., & Walker, B. (2016). Antiviral CD8(+) T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion.. Immunity, 45 (4). http://dx.doi.org/10.1016/j.immuni.2016.09.015
Peer Reviewed
1
Open Access
1
Included in
Cell and Developmental Biology Commons, Medical Immunology Commons, Medical Microbiology Commons, Tropical Medicine Commons, Virology Commons
Comments
Reproduced with permission of Elsevier B.V. Immunity