Document Type

Journal Article

Publication Date

4-2012

Journal

Parasitology

Volume

Volume 139, Issue 5

Inclusive Pages

641-650

Keywords

Genetic Vectors--genetics; Schistosoma--genetics

Abstract

Draft genome sequences for Schistosoma japonicum and S. mansoni are now available. The schistosome genome encodes ∼13 000 protein-encoding genes for which the functions of few are well understood. Nonetheless, the new genes represent potential intervention targets, and molecular tools are being developed to determine their importance. Over the past 15 years, noteworthy progress has been achieved towards development of tools for gene manipulation and transgenesis of schistosomes. A brief history of genetic manipulation is presented, along with a review of the field with emphasis on reports of integration of transgenes into schistosome chromosomes.

Comments

The published version is available at dx.doi.org/10.1017/S003118201100134X. Copyright © 2012 Cambridge University Press.

Peer Reviewed

1

Open Access

1

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