Single-nucleotide polymorphisms in PSCA and the risk of breast cancer in a Chinese population.

Authors

Meng Wang
Xijing Wang
Sidney W. Fu, George Washington UniversityFollow
Zhijun Dai
Tianbo Jin
+ 10 additional authors

Document Type

Journal Article

Publication Date

3-30-2016

Journal

Oncotarget

DOI

10.18632/oncotarget.8491

Abstract

This study explored the associations between common PSCA single-nucleotide polymorphisms (rs2294008, rs2978974, and rs2976392) and breast cancer among 560 breast cancer cases and 583 controls (Chinese Han women). We found rs2294008 was significantly associated with a high risk of breast cancer (homozygote model, odds ratio [OR]: 1.67, 95% confidence interval [CI]: 1.06–2.59; recessive, OR: 1.64, 95% CI: 1.06–2.53). And stratification by menopausal status revealed an association of the minor allele of rs2294008 with breast cancer risk among premenopausal (homozygote model, OR: 2.41, 95% CI: 1.03–5.66; recessive, OR: 2.80, 95 % CI: 1.21–6.47) and postmenopausal women (allele model, OR: 1.29, 95% CI: 1.01–1.65). Rs2978974 influenced the breast cancer risk among postmenopausal women in heterozygote model (OR: 1.47, 95% CI: 1.05–2.07). When stratified by clinicopathologic features, the T allele of rs2294008 was associated with progesterone receptor status (homozygote model, OR: 1.98, 95% CI: 1.08–3.63; recessive, OR: 1.87, 95% CI: 1.04–3.37), and the rs2976392 polymorphism was associated with high lymph node metastasis risk in homozygote model (OR: 2.09, 95%CI: 1.01–4.31). Further haplotype analysis suggested that T_rs2294008 A_rs2976392 G_rs2978974haplotype enhances breast cancer risk (OR:1.52, 95%CI:1.23-1.89, P<0.001). Therefore, among Chinese Han women, the PSCArs2294008, rs2978974, and rs2976392 minor alleles are associated with increased breast cancer risk especially in progesterone receptor positive breast cancer patients, with breast cancer risk in postmenopausal women, and with high lymph node metastasis risk, respectively. Moreover, T_rs2294008 A_rs2976392 G_rs2978974 haplotype was associated with significantly increased risk of breast cancer.

Comments

Reproduced with permission of Impact Journals LLC. Oncotarget

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.

APA Citation

Wang, M., Wang, X., Fu, S. W., Dai, Z., Jin, T., & + 10 additional authors (2016). Single-nucleotide polymorphisms in PSCA and the risk of breast cancer in a Chinese population.. Oncotarget, (). http://dx.doi.org/10.18632/oncotarget.8491

Peer Reviewed

1

Open Access

1