Document Type

Journal Article

Publication Date

5-2015

Journal

Journal of the American Heart Association

Volume

4

Issue

5

Inclusive Pages

e001695

DOI

10.1161/JAHA.114.001695

Keywords

Cardiovascular Diseases--ethnology; Ethnic Groups--ethnology; Metabolic Syndrome X--ethnology; Overweight--complications; Overweight--ethnology; Postmenopause--ethnology

Abstract

Background It is unclear whether obesity unaccompanied by metabolic abnormalities is associated with increased cardiovascular disease risk across racial and ethnic subgroups.

Methods and Results We identified 14 364 postmenopausal women from the Women's Health Initiative who had data on fasting serum lipids and serum glucose and no history of cardiovascular disease or diabetes at baseline. We categorized women by body mass index (in kg/m2) as normal weight (body mass index 18.5 to P=0.05). Obese black women without metabolic syndrome had higher adjusted risk (HR 1.95) than obese white women (HR 1.07; interaction P=0.02). Among women with only 2 metabolic abnormalities, cardiovascular risk was increased in black women who were overweight (HR 1.77) or obese (HR 2.17) but not in white women who were overweight (HR 0.98) or obese (HR 1.06). Overweight and obese women with ≤1 metabolic abnormality did not have increased cardiovascular risk, regardless of race or ethnicity.

Conclusions Metabolic abnormalities appeared to convey more cardiovascular risk among black women.

Comments

Reproduced with permission of the American Heart Assocation. JAHA.

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License

Peer Reviewed

1

Open Access

1

SHORT LIST OF WHI INVESTIGATORS.pdf (60 kB)
SHORT LIST OF WHI INVESTIGATORS

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