The Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS): Unifying Efforts to Inform Practice and Improve Global Outcomes in Peritoneal Dialysis

Jeffrey Perl, Arbor Research Collaborative for Health, Ann Arbor, Michigan, USA Division of Nephrology, The Keenan Research Centre in the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Canada jeff.perl@utoronto.ca.
Simon J. Davies, Health Services Research Unit, Institute of Science and Technology in Medicine, Keele University and University Hospitals of North Midlands,Stoke-on-Trent, United Kingdom.
Mark Lambie, Health Services Research Unit, Institute of Science and Technology in Medicine, Keele University and University Hospitals of North Midlands,Stoke-on-Trent, United Kingdom.
Ronald L. Pisoni, Arbor Research Collaborative for Health, Ann Arbor, Michigan, USA.
Keith McCullough, Arbor Research Collaborative for Health, Ann Arbor, Michigan, USA.
David W. Johnson, Australasian Kidney Trials Network, School of Medicine, University of Queensland, Brisbane, Australia Princess Alexandra Hospital, Brisbane, Queensland, Australia.
James A. Sloand, Baxter Healthcare, Deerfield, Illiniois, USA.
Sarah Prichard, Baxter Healthcare, Deerfield, Illiniois, USA.
Hideki Kawanishi, Akane Foundation, Tsuchiya General Hospital, Nakaku, Hiroshima, Japan.
Francesca Tentori, Arbor Research Collaborative for Health, Ann Arbor, Michigan, USA Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Bruce M. Robinson, Arbor Research Collaborative for Health, Ann Arbor, Michigan, USA Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.

Document Type

Journal Article

Publication Date

5-1-2016

Journal

Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis

Volume

36

Issue

3

DOI

10.3747/pdi.2014.00288

Keywords

Dialysis Outcomes Practice Patterns Study; peritoneal dialysis; prospective observational cohort study; survival; technique survival

Abstract

UNLABELLED: ♦ BACKGROUND: Extending technique survival on peritoneal dialysis (PD) remains a major challenge in optimizing outcomes for PD patients while increasing PD utilization. The primary objective of the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS) is to identify modifiable practices associated with improvements in PD technique and patient survival. In collaboration with the International Society for Peritoneal Dialysis (ISPD), PDOPPS seeks to standardize PD-related data definitions and provide a forum for effective international collaborative clinical research in PD. ♦ METHODS: The PDOPPS is an international prospective cohort study in Australia, Canada, Japan, the United Kingdom (UK), and the United States (US). Each country is enrolling a random sample of incident and prevalent patients from national samples of 20 to 80 sites with at least 20 patients on PD. Enrolled patients will be followed over an initial 3-year study period. Demographic, comorbidity, and treatment-related variables, and patient-reported data, will be collected over the study course. The primary outcome will be all-cause PD technique failure or death; other outcomes will include cause-specific technique failure, hospitalizations, and patient-reported outcomes. ♦ RESULTS: A high proportion of the targeted number of study sites has been recruited to date in each country. Several ancillary studies have been funded with high momentum toward expansion to new countries and additional participation. ♦ CONCLUSION: The PDOPPS is the first large, international study to follow PD patients longitudinally to capture clinical practice. With data collected, the study will serve as an invaluable resource and research platform for the international PD community, and provide a means to understand variation in PD practices and outcomes, to identify optimal practices, and to ultimately improve outcomes for PD patients.

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