Overcoming Barriers in Kidney Health-Forging a Platform for Innovation

Document Type

Journal Article

Publication Date

7-1-2016

Journal

Journal of the American Society of Nephrology : JASN

Volume

27

Issue

7

DOI

10.1681/ASN.2015090976

Keywords

Pathophysiology of Renal Disease and Progression; Patient satisfaction; clinical trial; end stage kidney disease; kidney disease

Abstract

Innovation in kidney diseases is not commensurate with the effect of these diseases on human health and mortality or innovation in other key therapeutic areas. A primary cause of the dearth in innovation is that kidney diseases disproportionately affect a demographic that is largely disenfranchised, lacking sufficient advocacy, public attention, and funding. A secondary and likely consequent cause is that the existing infrastructure supporting nephrology research pales in comparison with those for other internal medicine specialties, especially cardiology and oncology. Citing such inequities, however, is not enough. Changing the status quo will require a coordinated effort to identify and redress the existing deficits. Specifically, these deficits relate to the need to further develop and improve the following: understanding of the disease mechanisms and pathophysiology, patient engagement and activism, clinical trial infrastructure, and investigational clinical trial designs as well as coordinated efforts among critical stakeholders. This paper identifies potential solutions to these barriers, some of which are already underway through the Kidney Health Initiative. The Kidney Health Initiative is unique and will serve as a current and future platform from which to overcome these barriers to innovation in nephrology.

Share

COinS